Elevated hsCRP & Cholesterol - Need To Prevent Epithelial Cell Disease & Cancer
Dec 27, 2014
Hi Doctor Young, After starting on a protease inhibitor regimen (Reyataz, Norvir, Isentress & Sustiva) about nine years ago, I've noticed that my cholesterol levels and high sensitivity CRP are high. hsCRP=3.28 Note that I'm about 60 years old and have lots of Seborrheic Keratosis and a few Actinic Keratosis.
My HIV doc has suggested a statin because of both the above mentioned assays and because I have skin lesions (Actinic Keratosis).
Which statins are you prescribing and what measures are you following to verify efficacy? Do you measure IL-6?
Which inexpensive generic statins are FDA monitored (to avoid a "Ranbaxy")?
Are there any natural products (Boswellia, Cistanche tubulosa, Curcumin, EGCG) that can safely lower my hsCRP and Cholesterol?
Here are some random papers on the inhibition of inflammatory markers with natural ingredients:
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling Simon A. Jones, Jürgen Scheller, and Stefan Rose-John Published: September 2011 The Journal of Clinical Investigation Volume 121 Number 9 September 2011 Web: http://dx.doi.org/10.1172/JCI57158
Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes Amanda M Gonzales and Robert A Orlando Published: 12 June 2008 Nutrition & Metabolism 2008, 5:17 doi:10.1186/1743-7075-5-17 Web: http://www.nutritionandmetabolism.com/content/5/1/17
Synergistic anti-inflammatory effects of Laminaria japonica fucoidan and Cistanche tubulosa extract Jangbeen Kyung1, Dajeong Kim, Dongsun Park, Yun-Hui Yang, Ehn-Kyoung Choi, Sung-Pyo Lee, Tae-Su Kim, Yoon-Bok Lee, Yun-Bae Kim Published: Lab Anim Res | June, 2012 | Vol. 28, No. 2
Extracts of Cistanche deserticola Can Antagonize Immunosenescence and Extend Life Span in Senescence-Accelerated Mouse Prone 8 (SAM-P8) Mice Ke Zhang, Xu Ma, Wenjun He, Haixia Li, Shuyan Han, Yong Jiang, Hounan Wu, Li Han, Tomohiro Ohno, Nobuo Uotsu, Kohji Yamaguchi, Zhizhong Ma, and Pengfei Tu Published 9 January 2014 Evidence-Based Complementary and Alternative Medicine, Web: http://dx.doi.org/10.1155/2014/601383
Cistanche Tubulosa Extract (Marketing Brochure) ORYZA Oil & Fat Chemical Co., LTD. http://www.oryza.co.jp/html/english/pdf/Cistanche_tubulosa_ver2.0.pdf
The hypocholesterolemic effects of Cistanche tubulosa extract, a Chinese traditional crude medicine, in mice. Am. J. Chin. Med., 37(6), 1125-38, 2009.
Phenylpropanoids As Naturally Occurring Antioxidants: From Plant Defense To Human Health L.G. Korkina Published April 15th, 2007 Cellular and Molecular Biology http://www.cellmolbiol.com/admin/articles_generaux/Th%201%20-p15-25%20-Korkina.pdf
Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production Salahuddin Ahmed, Hubert Marotte, Kevin Kwan, Jeffrey H. Ruth, Phillip L. Campbell, Bradley J. Rabquer, Angela Pakozdi, and Alisa E. Koch Published: 1469214697 | PNAS | September 23, 2008 | vol. 105 | no. 38 Web: http://www.pnas.org/content/105/38/14692
Response from Dr. Young
Hello and thanks for posting.
There are many reasons why people living with HIV should be mindful of their cardiovascular risks, in part because (as noted in the NY Times article), there is a higher frequency of heart problems in the population.
The use of statin medications are widely recommended for the general population, and therefore for the positive population. Current recommendations don't necessarily indicate that poz's need to take them earlier. That said, it's reasonable to make sure that all of your cardiovascular disease risks are addressed, including your cholesterol levels.
It's not clear that actinic keratoses are related to HIV, nor are they related to cholesterol levels.
In our clinic, while we used to measure CRPs and occasionally IL-6, we no longer do so on a regular basis. Rather, it's trying to keep our eye on the range of primary care and preventive medicine recommendations, particularly as they apply to older individuals. This means optimal control of HIV, reduction or cessation of tobacco, regular exercise, prudent diet and optimal control of blood pressure and diabetes to name a few.
As for statins sold in the US, all are manufactured under FDA supervision, whether generic or brand name.
As you can read through these pages, I'm no fan of "natural products" that are sold without regulatory supervision for effectiveness or safety.
Hope that's helpful, and Happy New Year, BY
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