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Current status of Dolutegravir?
Mar 28, 2014

Hi Dr. Young. Could you tell me what the current status of Dolutegravir is? The last I heard it was in Phase III testing. I am currently using Isentress with no problems, but I understand that Dolutegravir is much more potent and less toxic. Will it be available soon?

Response from Dr. Young


Dolutegravir (Tivicay) was FDA approved in the US last summer. In first-line therapy, Tivicay and Isentress performed identically (search for the Spring-2 study); in second-line treatment for people with drug resistant virus, Tivicay appears to be more potent virologically.

The toxicity profiles of the two drugs are very similar.

Hope that helps. BY

Early Initiation of HAART 12 weeks after Exposure

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