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How long does it take for Truvada PrEP to be fully saturated and working?

Jan 9, 2014

Thank you for being there to answer my question. My husband will begin Truvada in the next few days. This is just part of our safer sex practices, but we would like to know the length of time it will take for Truvada to be fully effective within the bloodstream to assist in HIV protection. Thank you very much.

Response from Dr. Young

Hello and thanks for posting.

While levels of the drugs in Truvada will be present in the first hours after taking the drug, steady state levels take a few days longer.

It's not known exactly what dose is critical for PrEP, but protection should really start in the first couple of days.

As with all HIV medications, adherence (and maintenance of therapeutic levels) is critical for effectiveness.

Be well, BY

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