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What is the dosage (one or 2 tablets) of viraday or aleptra for a single day at PEP ?
Jan 4, 2014

Just today i have started PEP which consists of viraday and lopimune for 28 days, But my doctor prescribed the viraday daiily 2 tablets but every where on the internet it showing only one tablet daily? If i take daily 2 tablets that has any severe sideeffcts? Which one is right ? Please advice me , thank you

Response from Dr. Young

Hello and thanks for posting.

First, Viraday (known here in the US as Atripla) is dosed one pill, once daily (preferably at bedtime). Taking 2 Viradays won't have any serious toxicities, but the short-term side effects from efavirenz (psychological ones) could be greater.

Second, your PEP regimen is more than usually suggested. Lopimune (known here as Kaletra) can be part of a PEP regimen, but there's no need for a 4 drug regimen that you're taking. You could either stop the Lopimune and continue on the Viraday, or take 2 of the Viraday medications (tenofovir and emtricitabine) with the lopimune. Most experts don't recommend efavirenz for PEP because of the side effects and the somewhat higher rates of virus that are resistant to efavirenz.

Hope that helps, BY



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