Scared to discontinue PEP
Oct 11, 2013
Hi Dr Young, I recently had a high risk exposure, and tried to get on PEP, but only managed to do so about 85 hours after exposure. However, my clinician decided to put me on PEP as my exposure was particularly high risk (unprotected receptive with HIV positive ). I have been on PEP for about 8 days, and there has not been any seroconversion. I heard that seroconversion might occur after I stop taking PEP. My question then is, if I am pretty certain that I will seroconvert after stopping PEP, and PEP is keeping my seroconversion in check, should I continue to stay on PEP to stay seronegative, or can I at least continue taking PEP for a longer period to increase the chances of a functional cure ( I read the accounts of the 14 individuals in france who were functionally cured after taking HAART early during the infection phase).
Response from Dr. Young
PEP is very highly effective when taken early and with good adherence. There's little evidence that extending the treatment more than 28 days has any effect.
I'd not recommend continuing PEP, but rather have close and appropriate monitoring of your labs (and antibody tests) after the PEP treatment.
Be well, BY
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