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PEP treatment: Combivir without Kaletra
Sep 1, 2013

Hello, my best friend had sex with prostitute and condom broke (apparently just one crack). The women (prostitute) was one day before her menstruations. My friend took the prostitue to a hospital to make a test and it found out that she is HIV positive. I then took my friend to Hong Kong in order to get PEP treatment. The private hospital gave him some combivir tablets. I am however worried as I have read many posts saying that Combivir should be taken together with Kaletra. Did the hospital make a mistake? Please reply soon.

Response from Dr. Young

Hello and thanks for posting.

There are a variety of post-exposure prophylaxis regimens (PEP)- all include 2 nukes (NRTIs) such as Combivir or Truvada. Current US guidelines for sexual PEP usually includes a third medication, such as Kaletra or the integrase inhibitor raltegravir.

I'm not familiar with the protocols in Hong Kong, but I'd think that Combivir alone , especially if started within 72 hours and adhered to, should be adequate.

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