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why not a 4 drug regimen to battle resistance
Aug 28, 2013

hi, in 2013 we already have plenty of different category molecules in hand with lesser side effects. why dont we try a 4 drug regimen instead of 3 drug haart to cut down the odds of emergence of resistance more confidently? for example, what if we use tenofovir+lamivudine+efavirenz + raltegravir regimen? another question is, from ur exerience how long atripla can work for a patient with full adherence before it fails due to resistance? regards.

Response from Dr. Young

Hello and thanks for posting.

You raise an interesting question-- one that was previously the question of a number of large randomized clinical trials. The answer was that there was no measurable benefit from using 4, instead of 3 drugs for HIV-- either from an effectiveness or drug resistance perspective.

Indeed, if anything, adding a 4th drug probably only increases cost and risk of toxicity.

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