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Aug 20, 2013

Hi doctor, It's been posted that etravirine plus raltelgravir maintains virologic suppression. Since tivicay has a better resistance barrier than raltelgravir, could I simplify my triple therapy regime for tivicay and zelcentry? I'm on truvada and issentres and undetectable 900+ (no resistances)

Response from Dr. Young

Hello and thanks for posting.

Tivicay (dolutegravir), the new HIV integrase inhibitor has only a few significant drug-drug interactions, but turns out that it has a very significant interaction with etravirine- the two medications should only be taken together if taken also with a ritonavir-boosted protease inhibitor (such as atazanavir, darunavir or lopinavir).

As for simplification, you could consider switching out your twice-daily Isentress for the once-daily Tivicay- leading to a regimen of Truvada + Tivicay- a 2 pill, once-daily and well studied regimen.

Hope that helps, BY

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