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NanoArt
Aug 6, 2013

Is this true doctor? Is it true that is once a month injection treatment option? who will be able to use this ? Thanks in advance.

Response from Dr. Young

Hello and thanks for posting.

Nanoparticle formulation of HIV medications is under active investigation. If this works out, the formulation allows for very long acting injectable delivery of treatment.

One encouraging investigational drug is the integrase inhibitor S/GSK1265744 (744 for short). Very early results suggest that this formulation will allow for once- monthly (or even longer) dosing of this med. In one study in monkeys, once-monthly injection of 744 provided protective levels for pre-exposure prophylaxis (PrEP) against simian immunodeficiency virus. What is needed are additional long-acting formulations for treatment of chronically infected individuals.

So, who will benefit from nanoART? (I love your term) First, since PrEP is dependent of adherence to treatment, a once-monthly (or imagine, if you will, a every three month) treatment to prevent HIV would be a game changer. Second, chronically infected HIV+ people might benefit, but mostly if an entire regimen could be delivered as an infrequent injection. Groups are working on just such companion medications, including efforts with NNRTIs (non-nukes). New results on nanoparticle ART was presented at the IAS2013 meeting in Malaysia last month.

Stay tuned. I think that this will be a very exciting field in the months and years to come. BY



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