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care while taking PEP

Aug 4, 2013

Hi doctor, I am taking Kaletra(2 tabs twice a day) and Combivir (1 tab twice a day) together. I feeling very fatigue and some times some kind of stretch/little pain in right side of stomach. Blood test done on 9th july was ok and no lever malfunctioning was detected.

Please advice me what care I should take to avoid any lever damage.

Can I get sudden attack on my lever due these medicines?? Still I have to take medicine for 2 weeks.


Response from Dr. Young

Hello and thanks for posting.

You're worried about PEP causing liver injury, but this is generally uncommon with the short duration of treatment. If you're remotely concerned, I'd avoid alcohol and acetaminophen (Tylenol), since both can also cause liver injury.

Moreover, if you truly had a risky exposure and your worried about right-sided pain (ie., "could this be liver problems?"), I'd be much more concerned about the question about whether you were exposed to viral hepatitis (hep A, B or C). All of these can be sexually transmitted.

When in doubt, talk to your care provider.

Be well, BY

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