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New finding on CD4 death
Jul 26, 2013

Hi Dr. Young -

I read the articles listed here: http://www.thebodypro.com/content/71845/nih-scientists-discover-how-hiv-kills-immune-cells.html?ic=700100 http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12274.html

These results seem to indicate that an integrase inhibitor would help someone whose Tcells have not had a big rise. I feel like I fit in that category - low counts of 149 and high counts of 287 despite being undetectable for 2 years now. I am adherent on Atripla for 2 1/2 years now. Should I spreak with my HIV specialist about it?

Thank you! Mike

Response from Dr. Young

Hello Mike and thanks for posting.

Your idea is a reasonable one, though it may take a long time to confirm that this laboratory finding translates into meaningful clinical results. Indeed, studies that show slight differences in immune recovery fail to show clinical significance.

So, in isolation, I can't recommend switching an otherwise successful regimen on the basis of this early data. Nonetheless, we currently have 2 (and soon, 3) HIV integrase inhibitors- there may be other attributes that would warrant their consideration.

I hope that's helpful, and stay in touch, BY



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