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efavirenz and tenofovir
Jul 26, 2013

I was just reading that a study was performed that showed that smaller doses of efavirenz (1/3 less) are just as effective as the current prescribed dose and that there is a new formulation of tenofovir that results in a 90% less plasma concentration than the current formulation. As both of these are found in atripla do you think that the new formulations will be combined into a new atripla. This sounds like a real breakthrough in that atripla is still so widely used and reduced amounts could eliminate some of the side effects that some people suffer.

Response from Dr. Young

Hello and thanks for posting.

You're correct, a study presented at the IAS2013 conference suggests that 400 mg efavirenz is about the same as 600 mg (the standard dose) for people starting therapy. It will likely be a while before this is confirmed and adopted, especially into expensive-to-develop fixed dose formulations.

The new tenofovir formulation, called TAF is under active development, and appears to have lower toxicity ( kidney and bone) than the current TDF formulation. TAF is being developed for fixed dose formulations by Gilead Sciences.

Hope that helps, BY



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