|efavirenz and tenofovir
Jul 26, 2013
I was just reading that a study was performed that showed that smaller doses of efavirenz (1/3 less) are just as effective as the current prescribed dose and that there is a new formulation of tenofovir that results in a 90% less plasma concentration than the current formulation. As both of these are found in atripla do you think that the new formulations will be combined into a new atripla. This sounds like a real breakthrough in that atripla is still so widely used and reduced amounts could eliminate some of the side effects that some people suffer.
| Response from Dr. Young
Hello and thanks for posting.
You're correct, a study presented at the IAS2013 conference suggests that 400 mg efavirenz is about the same as 600 mg (the standard dose) for people starting therapy. It will likely be a while before this is confirmed and adopted, especially into expensive-to-develop fixed dose formulations.
The new tenofovir formulation, called TAF is under active development, and appears to have lower toxicity ( kidney and bone) than the current TDF formulation. TAF is being developed for fixed dose formulations by Gilead Sciences.
Hope that helps, BY
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