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Combinations of drugs

Mar 28, 2013

Is there a drug or drug therapy that combines nukes/non-nukes with Protease Inhibitors AND Integrase inhibitors. It seems that the current and newer combinations (whether it be in an individual pill or multiple pills) only use either Protease OR Integrase. Would not both be more effective? thanks!

Response from Dr. Young

Hello and thanks for posting.

I'm not sure where your information sources are, but all currently recommended regimens use two NRTIs (nukes) with either a NNRTI (non-nuke), protease inhibitor or integrase inhibitor.

In the past, studies looked at the question as to whether additional classes or medications (ie., 4 or 5 meds) would be more effective than 3- with the conclusion that there was no additional effectiveness and increased toxicity.

I hope that helps, BY

Kivexa and pregnancy

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