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Truvada to Kivexa

Mar 20, 2013

Hi Dr. Currently on Truvada + Viramune with great results except creatanine levels increasing from 0.9 - 1.26 mg/dl. The option is to change Truvada to Kivexa. Would Kivexa + Viramune be a workable comobo? I have taken Stocrin in the past but cannont tolerate it. thanks for your help

Response from Dr. Young

Hello and thanks for posting.

Yes, in cases of worsening kidney function a switch from Truvada to Kivexa would be very reasonable.

Here in the US (and in many other parts of the world), a genetic test called HLA B5701 is recommended prior to the switch- as people who are positive for this genetic marker are at greater risk of allergic reaction to abacavir (part of Kivexa/Epzicom). If negative, then there's no risk. If this test is not available where you live, then monitoring for the allergic reaction is important- it's something we did successfully for many years before the advent of the HLA test.

I hope that helps. Let us know how the switch works out for you. BY

Missing one of the three meds prescribed

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