Truvada to Kivexa
Mar 20, 2013
Hi Dr. Currently on Truvada + Viramune with great results except creatanine levels increasing from 0.9 - 1.26 mg/dl. The option is to change Truvada to Kivexa. Would Kivexa + Viramune be a workable comobo? I have taken Stocrin in the past but cannont tolerate it. thanks for your help
Response from Dr. Young
Hello and thanks for posting.
Here in the US (and in many other parts of the world), a genetic test called HLA B5701 is recommended prior to the switch- as people who are positive for this genetic marker are at greater risk of allergic reaction to abacavir (part of Kivexa/Epzicom). If negative, then there's no risk. If this test is not available where you live, then monitoring for the allergic reaction is important- it's something we did successfully for many years before the advent of the HLA test.
I hope that helps. Let us know how the switch works out for you. BY
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