Mar 2, 2013
Hello doctor, Any possibility dolutegravir could to be used as Monotherapy even though there's not available data yet?
| Response from Dr. Young
Hi and thanks for posting.
While the investigational integrase inhibitor dolutegravir has many positive attributes, there's no reason to think that this medication will work as monotherapy. Integrase inhibitors, generally speaking are similar to most other ARVs (except boosted PIs) in that only a couple of genetic mutations can confer high level drug resistance.
Having said that, like others, I'm anxiously awaiting the FDA approval of the medication sometime later this year.
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