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Jan 3, 2013

Dear doctor, So 2012 has ended. I woul like to know wath probabily news We will see in 2013? We ca have a new drug? researches aboute cure? thanks

Response from Dr. Young

Hi and thanks for posting.

2012 was indeed a big year for HIV treatments. 2013 will see additional developments- including the anticipated FDA approval of the third HIV integrase inhibitor, dolutegravir. Additional coformulations with the PK booster cobicistat (with protease inhibitors) and a new tenofovir compound are in late state development.

I'd expect to hear about refinements about pre-exposure prophylaxis (PrEP) and early stage development of medication formulations (such as nanoparticles) that permit once-monthly treatment.

Cure research had surprises in 2012, with the announcement of more apparent "cures" using bone marrow transplantation/gene therapy strategies. While not an approach for the general public, these portend of approaches to modify one's CD4s to protect from HIV infection and possible eradication.

We also saw compelling clinical trials data on the benefits in ART in preventing disease *and* preventing new infections. I'd expect to learn much more about the best ways to deliver treatment to all (sometimes called "test and treat").

Significant challenges clearly still exist, particularly in getting people into and productively in care, but tremendous progress has happened.

Happy new year to you, BY

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