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Innovations with drugs for HIV?
Nov 27, 2012

Has there been any innovative medicine that just got developed for HIV?

This seems like a stupid question, but if CCR5 is the receptor to which the HIV binds to the cell, why can't we make a membrane that has these receptors that has nothing inside? Like a hollow sphere almost... If there are various receptors for in one entity, wouldn't there be a greater chAnce of the virus infecting that compartment? Rather than the regular enemy? Once the DNA is injected, it cannot do anything, and would ultimately degrade...

I know many drugs now are ccr5 antagonists.

Sincerely,

A curious mind

Response from Dr. Young

Hi Curious,

Thanks for posting your thoughts. Not a stupid idea at all; there is a (single) CCR5 antagonist (maraviroc) that's approved for HIV treatment.

CCR5 decoys have been tried in the past, but have not (yet) proven to be effective. The idea of deploying decoys to both HIV coreceptors (CCR5 and CXCR4) on a single product is an interesting one though.

Be well, BY



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