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next to tenofovir?
Oct 20, 2012

dear doc, first we got adefovir which is now used only in hepa B. then came tenofovir. but we have not heard any congener to tenofovir without any cross resistance. why so? regards.

Response from Dr. Young

Hi and thanks for posting.

There is a prodrug congener of tenofovir, called GS-7340 in development. As a prodrug, it has the same active molecule as tenofovir DF and shares the same resistance profile. GS-7340 is in phase 3 clinical studies.

Other companies are working on nucleoside analogs with unique resistance profiles, but these are generally in early phase development.

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