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drug resistance
Oct 11, 2012

Ive became rsistance to virramune and was wondering can i take another medication in the same class as virramine

Response from Dr. Young

Hello and thanks for posting.

The answer depends on what drug resistance mutations your virus has accumulated. While resistance to nevirapine is often associated with resistance to other NNRTIs, some NNRTI-resistant virus retain susceptibility to the newer NNRTI etravirine.

According to the USCF InSite: Resistance to etravirine is associated with the selection of 1 or more of several resistance mutations. Clinical data in NNRTI-naive patients are needed to characterize de novo etravirine resistance. In patients with preexisting NNRTI resistance mutations and virologic failure on etravirine, a number of NNRTI mutations emerged, most commonly L100I, E138G, V179F V179I, Y181C Y181I, and H221Y; these were associated with decreased susceptibility to etravirine.



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