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Stocrin and Truvada as PEP

Oct 10, 2012

Hi there, I am one day into a PEP regime. I was prescribed Stocrin and Truvada. I started the course at 1000 in the morning - both pills - 24 hours after exposure. But due to the effects of Stocrin, was told to take the next dose at bedtime the following day - approx 36 hours after the first dose. Is this OK? Will the effectiveness of the PEP diminish as I am not taking the Stocrin at the same time as the day before?

Response from Dr. Young

Hi and thanks for posting.

We usually don't recommend using efavirenz (Stocrin, Sustiva) as part of PEP because of tolerability issues and the risk of transmitted drug resistance rendering the medication ineffective without resistance testing.

That said, it won't impair the activity of Truvada, so I won't get into the subject of alternatives or stopping your PEP here.

Efavirenz should be taken at bed time because of it's characteristic side effects. The 36 hour gap between your first and second dose probably won't have any significant consequences (especially since in most cases for PEP, Truvada alone is adequate).


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