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Just started medication and anxious!
Sep 7, 2012

Dear Dr I have started my medication with lamivudine+zidovudine twice per day and efavirenz on take at night before go to bed. I am really anxious about what to expect, no even single side effects so far, but it how much time should I have an overall improvement of my health? I started the medication with a count of 250 CD4 and 117,000 viral load, Thnak you Gonzalo

Response from Dr. Young

Hello Gonzalo and thanks for posting.

First, I would certainly agree that it was time to start HIV medications with your high (>100,000) viral load and CD4 count approaching AIDS-defining levels.

It's actually quite good that you've experienced no apparent side effects so far-- most people who have difficulty with medications have their worst symptoms in the first days of treatment. This is particularly true for efavirenz, so if you're not having the typical psychological symptoms, you're probably not going to have this issue. ZDV/3TC (Combivir, zidovudine+lamivudine) is likewise most apt to cause it's side effects (nausea, headache, fatigue) early, but is known to cause anemia and it's associated symptoms only after the first weeks of treatment. Lab tests can detect anemia before you become symptomatic. No mater what, it's important to stay linked into care with your doctors for continued monitoring of side effects or toxicity.

As for improvements in health, owing to the fact that you aren't experiencing side effects, I'd expect you to gradually feel better (perhaps more energetic, better appetite and the like) over the next weeks to months. Your viral load should decrease by more than 90% in the first month and reach very low or undetectable levels in 4-6 months. We usually see CD4 cells rise in excess of 200 cells in the first year of treatment.

I hope that's helpful. Please feel free to write back anytime. BY

Follow up question on 'Tenofovir and Lamivudine'
Gonzalo again

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