|Edurant side effects, safe to switch back to Reyataz?
Aug 15, 2012
58 yr. old male, HIV+ since 1997. Virus level undetectable one year after starting treatment, CD4 is usually 900 or above. Was on Reyataz/Epzicom, switched about 4 months ago to Viramune/Epzicom for a treatment with less impact on cholesterol. Developed serious allergic reaction to Viramune after 3 months, misdiagnosed by my HIV specialist, who insisted for two weeks that the reaction was just a nasty cold virus, despite my being covered in a rash, running extremely high (105-107) fevers, having severe joint issues -- in hindsight classic Viramune allergic symtoms. Stopped Viramune when allergy was confirmed by dermatologist -- liver enzymes were through the roof at that point, 600x normal, and I'd lost 14 pounds (my average weight is 165 pounds). Now on Edurant/Epzicom for three weeks and fear I'm developing side effects to Edurant -- itchy skin, numbness in limbs/mid torso, insomnia. I can't get an appointment to see my doctor for at least six weeks.
I still have Reyataz -- is it safe to stop Edurant and go back to the Reyataz/Epzicom combo that was working, albeit not good on cholesterol? Only other option I have is to go to an emergency room for evaluation. I really don't want to wait six weeks with the side effects that I'm experiencing.
| Response from Dr. Henry
In most cases would be OK to go back to the atazanavir you previously tolerated OK particularly if no history of drug resistance or much of a viral rebound since you have been on treatment. Atazanavir effects on cholesterol compare favorably to many other options so would not expect too dramatic of an effect so I am curious what your cholesterol (LDL specifically) did after starting the atazanvir/Epzicom the first time. KH
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