|Lowering VL with Truvada before starting Complera
Aug 11, 2012
I've read if you have a high VL and take Complera there is a higher chance of resistance.Is there any research or logic to take Truvada for a few weeks to knock VL down then take Complera?It seems on one level this would make sense.
| Response from Dr. Young
Hello and thanks for posting.
Complera has somewhat compromised potency in people with high initial viral loads (greater than 100,000). While the notion of using a more potent initial regimen is interesting, to my knowledge, not studies with Complera.
It makes no sense to "boost" Complera with Truvada, since 2/3 of Complera is comprised of the medications in Truvada. If one has a high initial viral load, it would make more sense to use any of the other guideline-recommended regimens that have effectiveness in people with high viral loads; then once undetectable, you could consider simplification strategies, if desired.
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