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cART, Diabetes and Wound Healing (additional info)
Aug 11, 2012

Do any of the boosted protease inhibitors, NNRTIs or integrase inhibitors, alone or in combination, cause diabetes? Since Ive started cART (long-time dual-NRTI user) Ive noticed that wounds are not healing well. My tests for diabetes are not remarkable for diabetes; at least my doctor hasnt mentioned it. What tests should I be getting to look for clinical diabetes when wound healing is an issue. Note that Im in my 50s and have been on ART for decades. I eat a pretty good diet and exercise regularly. What can I do to rule-in/rule-out the cause of my poor wound healing: 1)foot blisters & 2) toe discoloration (red/blue) from stubbing toes many months ago? Note that viral load has been undetectable for several years, CD4+ T cells are around 700-800 with a CD4/CD8 ratio of 1. Thank you.

Response from Dr. Young

Hello and thanks for posting.

Unlike many illnesses, diabetes is a pretty easy condition to diagnose. Aside from symptoms (increased thirst and urination), If your lab tests don't reveal evidence of elevated blood sugars (glucose levels or increased hemoglobin A1C (HgB A1C)) there's little chance that you have diabetes mellitus.

Your CD4 count values certainly sound excellent.

If your having difficulty with wound healing, I'd suggest speaking to your doctor about the situation. Perhaps there's more to the story. Perhaps (hopefully) not.

Hope that helps, BY

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