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Time guidelines for PEP
Jul 10, 2012

Hi Dr. young, I am 35 year male and had unprotected insetive intercourse with a unkown partner but she was high risk. I contracted my general physician who had put me on PEP (Combavir and Stocrin) for last 23 days. The recommended dosage is after break fast and after dinner. After going thorugh various web sites I came to know that these drugs will be less effective if not took properly. Can you pls guide me.

Response from Dr. Young

Hello and thanks for posting.

So long as you were taking your Combivir twice daily (as you are) and the efavirenz (Stocrin/Sustiva) once daily, your dosing is correct.

Because of the potential for unwanted side effects, efavirenz is usually dosed before bed time, but taking after dinner while not typical, has no negative consequences for effectiveness.

BTW, efavirenz is not usually used for PEP- we more commonly follow CDC guidelines that recommend using a boosted protease inhibitor (like Kaletra), or we'll prescribe the integrase inhibitor raltegravir (Isentress).

Be well, BY

Extremely scared even after a 12 week negative
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