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Negative PCR with many symptoms

May 30, 2012

Dear Dr. Question for your advice. I believe that I was infected in early January 2012, and I have been suffering many symptoms such as soar throat, night sweats, body aches, fatigue, thrush, gum bleeding and soars. I used AZT for 3 weeks in the 3rd month after exposure. However, the PCR HIV-1 test in Month 2 and PCR HIV-2 RNA test at the month 5 and antibody tests at month 1 to 5 are all negative. CD4 counts measured at month 2, 3, and 5 are 640, 535, and 730. I believed that I am infected because AZT helped a lot for symptoms, low cd4 counts, and I have those symptoms exactly related to HIV. I know that I can wait one month more to reach the 6 month period for antibody test. I am still suffering symptoms and feel horrible, but don't know what I can do. please help and advise.

Response from Dr. Young

Hi and thanks for posting.

I'm sorry to hear that you're not feeling well. You say that your symptoms are exactly HIV, but they're not exactly that at all. Your symptoms are very non-specific, meaning that many different things could be responsible.

What? You used AZT monotherapy? Bad idea. First off, if you were using it to prevent infection, PEP is only effective if started within 72 hours of exposure. If you were using AZT to treat HIV infection, monotherapy breeds drug resistant virus. Who provided the AZT? This would not be acceptable care by a healthcare provider.

Second, your lab tests, all of them, do not indicate HIV infection. Your CD4 counts are not low. Your PCR tests are negative.

Yes, you should have an antibody test (ELISA) at month 6 to be certain of not having HIV; but if you're suffering from symptoms (and this IS a common syndrome), you shouldn't prematurely narrow your diagnostic focus to just HIV. Indeed, you should be evaluated by a healthcare provider who can look at your symptoms and look broadly for the underlying culprit.

Be well, BY

Complera after 60 days
simple hiv question

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