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Increased dosage

May 16, 2012

If one is on Atripla can one increase the dosage to twice a day. What impact would it make on the viral load. Can it speed up the undetectable viral load status? Can one increase the dosage and revert back to once a day pill after the undetectable viral load status has been achieved?

Response from Dr. Young

Hello and thanks for posting your interesting question.

I wouldn't recommend taking Atripla twice daily- first, there's no evidence for safety (and likely, this would increase the efavirenz side effects, and possibly increase risk of kidney injury), and secondly, the medications are among the most potent in decreasing viral loads.

With the exception of integrase inhibitor-based therapies, all currently recommended treatment combinations drop viral loads at similar rates. Even when one considers the integrase regimens (Isentress), despite the very attractive rapid decreases in viral loads, there's little data that suggests that this feature has any clinical benefit.

I hope that's helpful, BY

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