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NNRTI and HIV Binding
Apr 9, 2012

Dear Dr, Once NNRTI drugs bind the HIV virus. Will the same HIV virus get released once you stop drugs or does it bind permanently.

Response from Dr. Young

Hello and thanks for posting.

NNRTIs bind non-competitively and reversibly to HIV reverse transcriptase enzyme. So once drug levels fall below critical levels, the enzyme is free to go about replicating HIV.

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