Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
   
Ask the Experts About

Choosing Your MedsChoosing Your Meds
           
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  
  • Email Email
  • Glossary Glossary


PEP Regimen Question
Mar 31, 2012

Thailand doctor gave me Stocrin 600mg once a day and Zilarvir (Lamivudine 150mg / Zidovudine 30mg) twice daily.

I just want to be sure this is the correct, and absolute best regimen I can be on for preventing HIV infection. I am flying home to the USA early and will get something else if this isn't the best.

I had two short sessions of unprotected vaginal sex with someone who has HIV. I took my first pills roughly 9 hours after exposure. She agreed to get tested immediately after the event and came up positive. Needless to say I am terrified.

I work in the medical industry and I am a little confused why there seems to be a random smorgasbord of regimens for pep. Surely they can't all be equal. Surely some meds are newer and better than older ones. I don't want to be on something marginally "okay" if there's better.

What is the latest, greatest, and strongest?

Response from Dr. Young

Hello and thanks for posting.

First, sounds like you were able to start your nPEP (non-occupational exposure, per se) very quickly after your exposure. This bodes well for the effectiveness of treatment in preventing HIV infection.

As for the treatment regimen, as you've said there's quite a bit of variation of recommendations. The most orthodox view is given in the various treatment guidelines. The World Health Organization (WHO) Guidelines include the use of ZDV/3TC (Combivir and others) with a HIV protease inhibitor. We'll typically use a ritonavir-boosted PI, such as ritonavir/lopinavir (Kaletra) or ritonavir/darunavir (Norvir/Prezista). Efavirenz is not generally used for PEP (in either the US or WHO guidelines) because of the relatively high rate of intolerance and risk of exposure to efavirenz-resistant virus.

Now that said, there are a variety of regimens that experienced care providers will use, based on knowledge of tolerability and risk of transmitted drug resistance. All of these regimens lack well powered clinical trials, but whose selection is base on the medications' activity in treating established HIV infection. Here in the US, tenofovir/FTC (Truvada) is often substituted for Combivir and increasingly entry inhibitors, like raltegravir (Isentress) for their better tolerability.

I hope that helps. Good luck, BY



Previous
Japan Move
Next
Atripla. alcohol and elevated liver enzymes

  
  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS


 
Advertisement



Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement