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Testicular Atrophy
Mar 31, 2012

2 mths after i started Truvada and Isentress my testosterone dropped out to 48 from the 600 range and I became completely impotent. They did an MRI to check my Pituitary glad and all was well. I am starting my 3rd mth of treatment, the Doctor placed me on testosterone shots of 100 mg 2x's a mth. I have only taken one shot, but a few weeks before i started taking the shots i noticed my testicles were kinda sore. The soreness has increased and i have noticed my testicles are shrinking. Can my treatment cause Testicular Atrophy? I'm worried, what can i do?

Response from Dr. Young

Hello and thanks for posting.

Low testosterone levels are quite common among men living with HIV. I generally don't associate this with the use of HIV medications, so your story is unusual.

It would seem like you have had an appropriate evaluation for underlying causes and the treatment is reasonable.

Testosterone replacement (or anabolic steroids as well) can cause atrophy (shrinkage) of the testicles. While concerning for cosmetic reasons, there's no significant medical consequence.

At a minimum, I'd let your healthcare provider know about your symptoms.

Be well, BY

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