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duovir N then atripla

Feb 19, 2012

hello doc, i am recently diagnosed and starting ART. i am from resource poor country and so i have access to duovir N only. can i switch to atripla / viraday from duovir N later without any problem when i have access to them? will there be any problem with efficacy or resistance problem regarding atripla/viraday if i make such sudden switch from duovir N in the midway when duovir N is doing well?

Response from Dr. Young

Hello and thanks for posting.

So long as there's no concerns about drug resistance (or virologic failure), there's no reason why you couldn't switch from Douvir-N (AZT/3TC/nevirapine) to Atripla/Viraday (tenofovir/FTC/efavirenz). I'd recommend making sure that your doctor checks your kidney function before switching; since tenofovir is associated with a small but present risk of kidney injury, particularly in persons with impaired kidney function.

I hope that helps, BY

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