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poppers / atripla
Feb 19, 2012

Hello doctor Young, I can't seem to find a consensus information regarding this subject. It looks like there is no systematic (and reliable) study to really address these questions, but I'd like to have your personal opinion based on your observation in the clinic. My question is , I am on Atripla, and I'd like to know if occasional (once weekly) use of poppers have really negative effects on my treatment (i.e. lowering CD4 counts and percentages, causing blips, etc) . Even though I am perfectly adherent to medication, I can't seem to increase my CD4 counts beyond 500 (around 26%). I have been on Atripla for 2 years, I started at CD4 = 320. And I had 3 blips (VL around 55) over the past 3 years. Thank you for your opinion.

Response from Dr. Young

Hi and thanks for posting.

While generally not exhaustively studied, there isn't thought to be any significant drug-drug interactions between HIV medications and amyl nitrate (poppers), nor significant effect on CD4s.

There are varied CD4 cell responses to treatments, some improve faster or more than others. I'd point out that your absolute CD4 count is normal, though percentage somewhat lower than the lower limit of normal. These values would suggest that your HIV-related health risks should be very, very low.

Hope that helps, BY

Truvada concern
CD4 count not rising

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