Feb 15, 2012
What is SB-728-T from sangamo? is it a possible cure? Do you think there will be any complete HIV cure in near future for HIV positives? regards.
| Response from Dr. Young
Hello and thanks for posting.
SB-728-T is a zinc-finger gene therapy approach to the treatment of HIV. The strategy involves the modification of the CCR5 gene on cells, rendering them relatively resistant to HIV infection. Phase II clinical trials are underway and early results suggest that the strategy lowers the circulating viral loads in persons treated. The current strategy is not a cure, per se, but could result in a so-called functional cure, where HIV-infected persons might have cells that are resistant to infection (but would probably still have virus in their blood).
Complete cure remains a very elusive goal, but these kinds of gene therapies and therapeutic vaccines could lead to a situation where positives might not have to take medicines on a daily basis.
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