Re-use of once failed regimen is possible?
Jan 7, 2012
Hi Doc, We imagine a scenario where after long use of a regimen based on 2 NRTIs and one NNRTI, all the HIV wild strains die and resistance strains get selected naturally and thus the regimen fail. Then the patient switches over to a second line with a protease inhibitor with tenofovir (if possible, we just imagine). And after long use of this second regimen again all the susceptibles die and the wild type again come in the population as majority along with the strains resistant against the first regimen. Is it possible to switch over again to the first regimen to get virological benefit based on the theory of natural selection? In brief, is it possible to re-use "a once upon a time" failed regimen?
Response from Dr. Young
Hi and thanks for posting your interesting question.
Generally speaking, once one's virus has developed resistance to a medication, that resistant virus remains in the body. This is because of the way that HIV infects cells, namely that the genetic library of the viral population becomes archived in the infected cells. Even after a second, or subsequent treatment regimen is used and the wild type population of virus is predominant, that archived resistant virus can rapidly reemerge once the "weakened" drug is reused. (This by the way is an unfortunate case study in real-time Darwinian evolutionary selection.)
So, it's not generally recommended to reuse medications that the virus had once upon a time had developed resistance.
Be well, BY
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Burning Red Spots After Giving Oral Sex What Are The Chances Of HIV
- Itchy Vagina After Touching Skin Sign Of HIV AIDS
- Pain In Penis After Reused Needle Worried I Have HIV
- Painful Urination After Oral Sex On A Woman What Are The Chances Of HIV
- Sore On Mouth After Kissing Cut On Lip Worried I Have HIV
- Can Bacterial Vaginosis Cause Vaginal Bleeding?
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.