Dec 19, 2011
When will you start to use an entry inhibitor and can it be combined with EFV, 3TC and TDF?Patient is stable on EFV,3TC and TDF the CD4 count remains at 470- 475 with undetectable Viral Load rest of blood results normal.Do I need to change the regime.I am interested 6to know when do one use entrance inhibitors.I have asked experts on HIV and cannot get a clear answer.Regards Dr.F.Booyens South Africa
Response from Dr. Young
Hello Dr. Booyens and thanks for your post from South Africa.
Entry inhibitors (maraviroc, MVC) have been added to the US list of alternative first-line agents. While most of the literature on MVC is derived from the treatment-experienced clinical trials, there are also data for first line use from the Merit clinical study.
There's no data that I'm aware of adding MVC combination with TDF/3TC and EFV- nor would I expect significant additional benefit in a patient already experiencing viral suppression on the regimen.
Here in the US, we use MVC in patients with CCR5-tropic virus, either to construct a potent regimen in drug-resistant patients, or for select first-line patients who have relative contraindications for the use of more orthodox 3rd agents (NNRTIs, PIs). Our experience has been positive, with excellent tolerability to date.
I hope that helps. Please feel free to write me back with any follow up questions. BY
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Is Unprotected Sex Without Ejaculation Safe?
- How Likely Is It To Get AIDS From Sex With A Prostitute?
- Can AIDS Be Transmitted Through Blowjob From A Prostitute?
- Hpv After Breast Sucking Sign Of HIV AIDS
- Itchy Rash After Touching Dried Semen Sign Of HIV AIDS
- Itchy Testicles After Sex With Sex Worker Sign Of HIV AIDS
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.