The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

Choosing Your MedsChoosing Your Meds
Rollover images to visit our other forums!
  • Email Email
  • Glossary Glossary

Holes in immune system
Dec 8, 2011

Hi, I was wondering if you could talk more about the "holes in the immune system" which I have seen in a couple different places on this site. (including in Dr. Steve's account of Dr. Bob's death) I was wondering what that means and why it happens. Thank you, susan

Response from Dr. Young

Hello Susan and thanks for posting.

When we speak about "holes in the immune system", we are referring to gaps in the repertoire of the immune response. If you think of the universe of things that our immune system is supposed to react to (ie., infections, toxins, cancers) as a slice of American cheese, think of an immune system with holes as a slide of Swiss cheese. Each hole represents that part of the immune system that is responsible to fight a specific target.

Things that fall through the holes are diseases that can occur in persons with immune system problems that might not be as severe in those who have healthy immune systems. It appears that there are sometimes these gaps or holes in the recovered immune systems among persons living with HIV and normal CD4s. One theory is that these holes are created when one's disease state is more advanced (AIDS, with low CD4s), and that while ART improves the numbers and fills many of the holes, for some people, holes can still persist. The risk then is if the right pathogen finds the immune system with the corresponding hole.

I hope that metaphor helps. BY

missed doseges for 10 days w/epiziom
will the bloating feeling stop

  • Email Email
  • Glossary Glossary



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint