how to switch from daily dose of Isentress to twice daily
Oct 26, 2011
I've been taking Truvada and Isentress for the past 18 months with great results....undetectable and cd 4 count of 500 with no side effects....I was taking Isentress 2 pills once a day instead of the recommended dosage of one pill twice daily..After a phase three study was finished, Merck is recommending that patients taking once daily dosing should switch to isentress twice daily....How do i go about this to insure there is an adequate amount of isentress in my bloodstream...for fear of viral mutation and drug resistance....And do you think it was correct for my hiv specialist to suggest that i could take the once daily dose before all studies were in....and shouldn't the specialist alert me to Mercks recommendation....It doubting his judgement....thanks stan
Response from Dr. Young
Hi and thanks for posting.
Yes indeed, the QDMRK study (recently published in Lancet Infectious Diseases ) showed that once-daily raltegravir (ISENTRESS) didn't perform quite as well as when taken twice daily. [NB: I was an author on the study] The differences weren't huge, but large enough to be statistically significant.
If you're currently taking once daily ISENTRESS, just start a new day taking 1 pill in the morning and 1 in the evening. Since the drug levels are at normal levels, there shouldn't be any problem in the change.
As for whether it was correct or not to start on once-daily, it's a matter of opinion and how much clinical trials evidence it takes for clinicians to feel comfortable with a new dose or new drug. In my opinion, since we have so many well tested regimens (and doses), that there's usually little need to prematurely experiment with things that are theoretical and haven't yet been proven using good scientific method. I suspect that since your doubting the judgment of your specialist, it's time for a non-judgmental heart-to-heart discussion.
Hope that helps, be well, BY
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Alphabetical List Of Sexually Transmitted Diseases
- Can A Sexually Transmitted Disease Cause A Sore On Your Gums?
- Can Men Get Genital Warts Around Their Anus?
- Lower Back Pain And Abnormal Vaginal Bleeding
- Can Corticosteroid Cream Affect Hiv Test Results?
- Can Hiv Transmitted Through Sucking Breast?
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.