Azothioprine/Mercaptopurine and MDMA
Oct 13, 2011
What are the SPECIFIC dangers of taking MDMA while on Azothioprine/Mercaptopurine?
Response from Dr. Young
Thanks for posting.
It's good that you're asking about potential issues with combining recreational drugs and medications. Unfortunately, this is not often a well studied subject.
MDMA (otherwise known as Ecstasy, X, E) has the potential for drug-drug interactions, particularly with medications that are metabolized using the cytochrome P450 pathway. Indeed, there have been case reports of fatalities resulting from the use of X in persons taking the most potent P450 inhibitor (and HIV medication), ritonavir.
Azthioprine(Imuran) and mecaptopurine also have the potential for specific drug-drug interactions, but not with P450 nor MDMA.
Hope that helps. Be safe, BY
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