Sep 28, 2011
My Cholesterol LDL is out of control, HDL is great. I am trying to prove that the Kaletra I was put on(in extreme amounts by mistake by a drunk and HIGH Physicians Assistant, for PEP) is the link to my explosive cholesterol. Do you have any research backing the side effects of Kaletra on cholesterol?
Response from Dr. Young
I can't say much about the inebriated health care provider, nor the assessment of your exposure risk. However, the current US post-exposure prophylaxis guidelines recommends the use of KALETRA (lopinavir/ritonavir) with two nucleoside RT inhibitors for high risk HIV exposures. The recommended dose of KALETRA is 400 mg/100 mg (two tablets) twice-daily, or 800 mg/200 mg (four tablets) once-daily.
Elevations in cholesterol and triglycerides are well documented (and published) side effects of many HIV medications, including lopinavir/ritonavir. Why exactly you got your cholesterol evaluated in the middle of your PEP treatment is unclear, but something that I wouldn't necessarily take as an assessment of irreversible toxicity. A reassessment of your cholesterol and triglycerides after you complete your PEP will determine what your true baseline values are.
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