The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

Choosing Your MedsChoosing Your Meds
Rollover images to visit our other forums!
  • Email Email
  • Glossary Glossary

Protease Structure
Sep 24, 2011

A news report today said that a new computer program has enabled gamers to help figure out the structure of protease and that this breakthrough will lead to new drugs being developed. There are already lots of protease inhibitors on the market so I don't understand two things, 01. how were the current protease inhibitors developed if the structure of protease was not known, 02. how will these new drugs be different from the current protease inhibitors. It sounds to me as though there are different kinds of protease but I have never heard of protease being labeled as to there being more than one kind.

Response from Dr. Young

Hi and thanks for posting.

The HIV protease inhibitors were designed with the knowledge of the atomic structure of the HIV protease. What's new is the idea of using gaming technology to get communities of people involved in design of drugs.

There are multiple protease enzymes throughout biology, including in viruses and humans. What makes this work for HIV and HCV is that they each have one key protease and the enzymes are exquisitely specific for the viral precursor proteins (and not human proteins).


Insurance Endings Going From Atripla to Self Pay Generic

  • Email Email
  • Glossary Glossary



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint