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risk of discontinuing tenofovir...how safe is it to stop?
Jun 26, 2011

Regarding hepatitis B treatment with tenofovir, is it generally presumed safe to discontinue tenofovir under a doctor's supervision...if necessary? If not, is the risk of wild replication great, and if so, possibly unavoidable?

Response from Dr. Young

Hello and thank you for your post.

Just so we're clear, I'll assume that you had chronic hepatitis B (ie., positive HBV DNA PCR-viral load).

Since tenofovir actively suppresses HBV (unless there's drug resistance), discontinuation of previously suppressive tenofovir treatment can result in reactivation of HBV. Reactivation in some individuals can cause a flair in liver inflammation, or hepatitis. Other than switching to other HBV medications, this risk isn't really unavoidable, but should be monitored in the weeks following discontinuation.

I hope this is helpful, be well. BY



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