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sustiva mutation
Jun 25, 2011

Hello,

How long does this resistance mutation lives without meds?

If somebody develop resistance to sustiv, will other drug kill this mutated virus? OR Is it just satys in the body fore ever

Thank you very much

Response from Dr. Young

Hello and thank you for your post.

The typical efavirenz (SUSTIVA, STOCRIN) resistance mutation is called K103N. When acquired during initial infection, the mutation can persist for many years, even in the absence of medications. If the mutation emerges as the result of treatment failure, K103N is readily detected by commercial assays for the weeks following treatment discontinuation, but then (at least in some patients) will disappear from detection. The real issue is that CD4 cells infected with the mutated virus can persist for years, below the level of detection.

Fortunately, there are a wide variety of medications that will treat viruses that are resistant to efavirenz, including the second-generation NNRTI etravirine (INTELENCE).

Hope that helps, BY



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