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40 Minutes late taking dose....

Mar 23, 2011

This question is for Dr. Young. Recently someone inquired if he/she is in danger of developing resistance to his ARV because he/she was 40 mins late in taking his meds.

Your reply was "you have to completely miss 5% of your medication doses before we can measure any increased risk of treatment failure or drug resistance.

I'm not sure what missing 5% applies to? What percentage would equal to 40 mins? I too am on Darunavir and Truvada and Norvir and recently changed my schedule to morning doses from evening dosing as I'm more apt to eat breakfast at the same time and dinnertime can vary 1-3 hours depending on my schedule. Did I do myself harm from switching my schedule? I made the change over 3 days by delaying my dose 2-3 hours until I reached my target. Please advise. Thank you.

Response from Dr. Young

Thanks for your post.

A 5% miss means completely skipping 1 dose in 20, not being late (at 40 minutes, or 1-3 hours, IMHO isn't late).

So, worry not, BY

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