Why do T Cells drop to Baseline ?
Mar 20, 2011
I have looked through the forums...un able to get exact answer. My base line before ARV CD4 40, Viral L 1,000,000 + I have tried drug interuptions and both times, My cd4 drops rapidly. Last cd4 count 380, after interuption of 4weeks back down to 175 cd4? I am just curious why the t cells dont stay stable?
Response from Dr. Young
Hello and thanks for your post.
It's not entirely clear why CD4s drop rapidly after treatment discontinuation; but what is clear that after discontinuation of HAART, CD4 levels will decrease and eventually approach pre-treatment levels. In my simple view, this represents some kind of immunological scarring that HIV/AIDS imprints on the immune system and might not be a reversible as the absolute CD4 cell count on treatment.
For someone like you, with a low initial CD4 cell count, this history predicts rapid decline-- exactly what you've described, and perhaps a reason to avoid drug interruptions.
Hope this helps, BY
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