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Atripla Resistance
Nov 6, 2010

Hello, I've been told by the pharmicist at my hosital (HIV Dept.) that my genotype test shows my virus has become resistant to Atripla. My viral load has been undetectable, but my last labs shows it at about 1,000. Is this viral load too low to warrant changing my meds? THANKS

Response from Dr. Young

Hello and thanks for your post.

The question of when to switch therapies in the setting of known drug resistance isn't based on a viral load, but rather on the risk of developing further drug resistance. Continuing on treatment when 1 or 2 of the current treatment isn't fully active risks the development of further drug resistance (or worse, cross resistance) and jeopardizing future treatment options.

So, continuing Atripla could risk the loss of future NRTI or NNRTI treatment options.

The specifics of your situation depends a lot on exactly which drug resistance muatations are evident on the genotypic resistance test; but typically, we'd switch to a boosted protease inhibitor and at least one, if not two additional active HIV medications.

I hope you find this helpful. Be well, BY

Atripla, How long to become undetectable
why would i get kaletra and prezista (?) for exposure only?

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