Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
   
Ask the Experts About

Choosing Your MedsChoosing Your Meds
           
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  
  • Email Email
  • Glossary Glossary


Dosage Reductions?
Oct 21, 2010

I am currently taking Norvir, Truvada, and Reyataz all at the maximum dosage level. I know that continued use of some strong medications over time can cause liver damage. My friends have also noticed that since I have begun taking these meds, my eyes have been yellow. So, I'm wondering if my liver is being affected. I am undetectable and my T count is over 700. Would it be in my best interest to ask about a reduction in the dosage?

Response from Dr. Young

Hello and thanks for your post.

Dose reductions of HIV medications is generally not recommended. The reason for this is that the dose that is used is that which achieves sufficient levels in the blood to stop the virus from reproducing.

Continued use of "strong medications" doesn't necessarily doom you to liver damage, but proper monitoring for side effects and toxicity should help make sure that you don't get into difficulty.

Yellowing of the eyes and skin is a not uncommon side effect of atazanavir (Reyataz) and while disconcerting, is not a sign of significant liver toxicity (unless something else is the cause). The skin color changes you describe are the result of increased levels of the chemical bilirubin in your blood. In the specific case of 'Taz, it's because the medication slows down the body's elimination of the chemical, rather than liver injury.

If this side effect is problematic for you, a switch to a different medication (or to an unboosted atazanavir (ritonavir-free) regimen; but that would also require a switch off of Truvada) could be a solution.

I hope this helps, BY



Previous
missed day 2 of Truvada
Next
drop the ziagen?

  
  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS


 
Advertisement



Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement