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Reducing my medications

Mar 3, 2010

I was diagnosed one year ago, and am undetectable now with a CD4 of 830. I had been taking Truvada with Reyataz and Norvir, but when my recent labs came out in January my doc dropped all but the Truvada. She said it should maintain my levels fine alone and has more concerns about long term side effects of the other drugs than the possibility of my counts changing. Should I be concerned that not continuing the other two drugs could cause a change that will be difficult to counter act in six months?

Response from Dr. Young


Your absolutely correct to be concerned.

There is no scientific- or guideline-based recommendation for the use of tenofovir/FTC (Truvada) alone as maintenance treatment for HIV; even after successful initiation with Truvada with Norvir-boosted atazanavir (Reyataz). I'd be very concerned about the risks of developing drug resistance to the components of Truvada. There are data about a different induction-maintenence regimen with the use of abacavir/3TC (Epzicom) with atazanavir following initiation with Norvir-boosting (ie., simplification by stopping the Norvir), but that still leaves one on a three drug regimen.

I hope that you and your doctor have misunderstood one another. Perhaps your doctor is not familiar with current US Treatment Guidelines. Either way, I would definitely not recommend stopping or altering your already very successful regimen until this is sorted out.

Please write us back and let us know how this proceeds.

Be well, BY

Absorption of Meds

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