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Single v. Twice a Day Dose; Isentress/Truvada
Dec 21, 2009

I am on the trial for the single vs. twice a day dosing for Isentress/Truvada. I am undetectable and my latest numbers at the end of October were 544 at 23.1% after 11 months of therapy, which puts me right at the threshold for what is supposed to be a normal absolute CD4 number for a man of 46 (the percentage remains out of whack yet improving.) Have there been news reported on the efficacy of one type of dosing v. the other in the study? I am always stressing about timing of dosing so it would be so nice to only have to take the pills, w once a day and thus stress out only a day!

Response from Dr. Young

Hello and thanks for your post and participation in the clinical trial.

To my knowledge, there has been no early release of information from the once- vs twice-daily raltegravir (Isentress) study. My best hunch is that the medication will likely perform as well whether dosed once- or twice-daily, but that is the subject of the study.

That said, there is a fair bit of leeway in dosing of current medications. I generally say that if your within 2-4 hours of your target time of dosing, you needn't worry at all.

Hopefully, the study will confirm that the dosing effectiveness is the same, so stay tuned.

Be well, BY



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