HIV/HSV2 treatment adherence
Oct 4, 2009
If near-perfect adherence to HIV meds is essential to minimizing chances for drug resistance, are there any additional concerns in HIV/HSV2 coinfection? Do herpes antivirals present similar concerns of resistance or treatment failure when adherence is not perfect?
Response from Dr. Young
Hello and thanks for your interesting question.
First, fortunately HSV (herpes) resistance to acyclovir medications is uncommon-- far less of an issue than HIV drug resistance. It seems that the major factor isn't adherence per se, but the degree of immune suppression of the patient. Namely acyclovir resistance is most common in persons whose immune system does a particularly bad job in helping to control herpes. In persons with healthy immune systems, resistant HSV is quite rare.
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