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T-Cell/CCR-5 diversionOct 2, 2009 Hi Doctor I'm learning about the way T-Cells with CCR-5 interact with HIV and how people with no CCR-5 can become immune because of the limitation to the interaction. As i think about it I wonder if it is possible to divert HIV to interact with something else that looks like a T-Cell because it has CCR-5. I'm thinking a harmless bacteria with the same CCR-5 characteristics that T-Cells have, and maybe one that the T-Cells can cope with. Couldn't something like this lead to the viral load dropping and being kept under control. Thanks for site, we need all the support we can get |
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| Response from Dr. Young Hi and thanks for your post and words. What you've described is a CCR5 decoy-- this is an interesting idea; tried in the past and unfortunately didn't seem to yield any interesting initial results. Nevertheless, blockade of the human CCR5 molecule does inhibit HIV replication-- evidenced by the clinical utility of the drug maraviroc (Selzentry). Be well, BY | ||||||||
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